Risk Assessment of H2N2 Influenza Viruses from the Avian Reservoir
Identifieur interne : 000670 ( Main/Exploration ); précédent : 000669; suivant : 000671Risk Assessment of H2N2 Influenza Viruses from the Avian Reservoir
Auteurs : Jeremy C. Jones ; Tatiana Baranovich ; Bindumadhav M. Marathe ; Angela F. Danner ; Jon P. Seiler ; John Franks ; Elena A. Govorkova ; Scott Krauss ; Robert G. WebsterSource :
- Journal of Virology [ 0022-538X ] ; 2014.
Descripteurs français
- KwdFr :
- Animaux, Animaux sauvages (virologie), Furets, Grippe chez les oiseaux (virologie), Grippe humaine (virologie), Humains, Lignée cellulaire, Oiseaux, Réplication virale, Réservoirs d'agents pathogènes (virologie), Souris, Souris de lignée DBA, Sous-type H2N2 du virus de la grippe A (génétique), Sous-type H2N2 du virus de la grippe A (isolement et purification), Sous-type H2N2 du virus de la grippe A (pathogénicité), Sous-type H2N2 du virus de la grippe A (physiologie), Suidae, Évaluation des risques.
- MESH :
- génétique : Sous-type H2N2 du virus de la grippe A.
- isolement et purification : Sous-type H2N2 du virus de la grippe A.
- pathogénicité : Sous-type H2N2 du virus de la grippe A.
- physiologie : Sous-type H2N2 du virus de la grippe A.
- virologie : Animaux sauvages, Grippe chez les oiseaux, Grippe humaine, Réservoirs d'agents pathogènes.
- Animaux, Furets, Humains, Lignée cellulaire, Oiseaux, Réplication virale, Souris, Souris de lignée DBA, Suidae, Évaluation des risques.
English descriptors
- KwdEn :
- Animals, Animals, Wild (virology), Birds, Cell Line, Disease Reservoirs (virology), Ferrets, Humans, Influenza A Virus, H2N2 Subtype (genetics), Influenza A Virus, H2N2 Subtype (isolation & purification), Influenza A Virus, H2N2 Subtype (pathogenicity), Influenza A Virus, H2N2 Subtype (physiology), Influenza in Birds (virology), Influenza, Human (virology), Mice, Mice, Inbred DBA, Risk Assessment, Swine, Virus Replication.
- MESH :
- genetics : Influenza A Virus, H2N2 Subtype.
- isolation & purification : Influenza A Virus, H2N2 Subtype.
- pathogenicity : Influenza A Virus, H2N2 Subtype.
- physiology : Influenza A Virus, H2N2 Subtype.
- virology : Animals, Wild, Disease Reservoirs, Influenza in Birds, Influenza, Human.
- Animals, Birds, Cell Line, Ferrets, Humans, Mice, Mice, Inbred DBA, Risk Assessment, Swine, Virus Replication.
Abstract
H2N2 influenza A viruses were the cause of the 1957-1958 pandemic. Historical evidence demonstrates they arose from avian virus ancestors, and while the H2N2 subtype has disappeared from humans, it persists in wild and domestic birds. Reemergence of H2N2 in humans is a significant threat due to the absence of humoral immunity in individuals under the age of 50. Thus, examination of these viruses, particularly those from the avian reservoir, must be addressed through surveillance, characterization, and antiviral testing. The data presented here are a risk assessment of 22 avian H2N2 viruses isolated from wild and domestic birds over 6 decades. Our data show that they have a low rate of genetic and antigenic evolution and remained similar to isolates circulating near the time of the pandemic. Most isolates replicated in mice and human bronchial epithelial cells, but replication in swine tissues was low or absent. Multiple isolates replicated in ferrets, and 3 viruses were transmitted to direct-contact cage mates. Markers of mammalian adaptation in hemagglutinin (HA) and PB2 proteins were absent from all isolates, and they retained a preference for avian-like α2,3-linked sialic acid receptors. Most isolates remained antigenically similar to pandemic A/Singapore/1/57 (H2N2) virus, suggesting they could be controlled by the pandemic vaccine candidate. All viruses were susceptible to neuraminidase inhibitors and adamantanes. Nonetheless, the sustained pathogenicity of avian H2N2 viruses in multiple mammalian models elevates their risk potential for human infections and stresses the need for continual surveillance as a component of prepandemic planning.
Url:
DOI: 10.1128/JVI.02526-13
PubMed: 24227848
PubMed Central: 3911670
Affiliations:
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Le document en format XML
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<term>Cell Line</term>
<term>Disease Reservoirs (virology)</term>
<term>Ferrets</term>
<term>Humans</term>
<term>Influenza A Virus, H2N2 Subtype (genetics)</term>
<term>Influenza A Virus, H2N2 Subtype (isolation & purification)</term>
<term>Influenza A Virus, H2N2 Subtype (pathogenicity)</term>
<term>Influenza A Virus, H2N2 Subtype (physiology)</term>
<term>Influenza in Birds (virology)</term>
<term>Influenza, Human (virology)</term>
<term>Mice</term>
<term>Mice, Inbred DBA</term>
<term>Risk Assessment</term>
<term>Swine</term>
<term>Virus Replication</term>
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<term>Animaux sauvages (virologie)</term>
<term>Furets</term>
<term>Grippe chez les oiseaux (virologie)</term>
<term>Grippe humaine (virologie)</term>
<term>Humains</term>
<term>Lignée cellulaire</term>
<term>Oiseaux</term>
<term>Réplication virale</term>
<term>Réservoirs d'agents pathogènes (virologie)</term>
<term>Souris</term>
<term>Souris de lignée DBA</term>
<term>Sous-type H2N2 du virus de la grippe A (génétique)</term>
<term>Sous-type H2N2 du virus de la grippe A (isolement et purification)</term>
<term>Sous-type H2N2 du virus de la grippe A (pathogénicité)</term>
<term>Sous-type H2N2 du virus de la grippe A (physiologie)</term>
<term>Suidae</term>
<term>Évaluation des risques</term>
</keywords>
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<front><div type="abstract" xml:lang="en"><p>H2N2 influenza A viruses were the cause of the 1957-1958 pandemic. Historical evidence demonstrates they arose from avian virus ancestors, and while the H2N2 subtype has disappeared from humans, it persists in wild and domestic birds. Reemergence of H2N2 in humans is a significant threat due to the absence of humoral immunity in individuals under the age of 50. Thus, examination of these viruses, particularly those from the avian reservoir, must be addressed through surveillance, characterization, and antiviral testing. The data presented here are a risk assessment of 22 avian H2N2 viruses isolated from wild and domestic birds over 6 decades. Our data show that they have a low rate of genetic and antigenic evolution and remained similar to isolates circulating near the time of the pandemic. Most isolates replicated in mice and human bronchial epithelial cells, but replication in swine tissues was low or absent. Multiple isolates replicated in ferrets, and 3 viruses were transmitted to direct-contact cage mates. Markers of mammalian adaptation in hemagglutinin (HA) and PB2 proteins were absent from all isolates, and they retained a preference for avian-like α2,3-linked sialic acid receptors. Most isolates remained antigenically similar to pandemic A/Singapore/1/57 (H2N2) virus, suggesting they could be controlled by the pandemic vaccine candidate. All viruses were susceptible to neuraminidase inhibitors and adamantanes. Nonetheless, the sustained pathogenicity of avian H2N2 viruses in multiple mammalian models elevates their risk potential for human infections and stresses the need for continual surveillance as a component of prepandemic planning.</p>
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<name sortKey="Danner, Angela F" sort="Danner, Angela F" uniqKey="Danner A" first="Angela F." last="Danner">Angela F. Danner</name>
<name sortKey="Franks, John" sort="Franks, John" uniqKey="Franks J" first="John" last="Franks">John Franks</name>
<name sortKey="Govorkova, Elena A" sort="Govorkova, Elena A" uniqKey="Govorkova E" first="Elena A." last="Govorkova">Elena A. Govorkova</name>
<name sortKey="Jones, Jeremy C" sort="Jones, Jeremy C" uniqKey="Jones J" first="Jeremy C." last="Jones">Jeremy C. Jones</name>
<name sortKey="Krauss, Scott" sort="Krauss, Scott" uniqKey="Krauss S" first="Scott" last="Krauss">Scott Krauss</name>
<name sortKey="Marathe, Bindumadhav M" sort="Marathe, Bindumadhav M" uniqKey="Marathe B" first="Bindumadhav M." last="Marathe">Bindumadhav M. Marathe</name>
<name sortKey="Seiler, Jon P" sort="Seiler, Jon P" uniqKey="Seiler J" first="Jon P." last="Seiler">Jon P. Seiler</name>
<name sortKey="Webster, Robert G" sort="Webster, Robert G" uniqKey="Webster R" first="Robert G." last="Webster">Robert G. Webster</name>
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